About Us
Founded in 2010, Fardilha’s Laboratory is part of the Institute for Biomedicine (iBiMED) at the University of Aveiro, in Portugal.
Our research explores the molecular mechanisms underlying male infertility and prostate cancer, aiming to identify new molecular targets for diagnosis, prognosis, treatment, and male contraception.
At the heart of our work is protein phosphorylation, a key regulatory process in eukaryotic cells. We focus particularly on Phosphoprotein Phosphatase 1 (PPP1)—one of the most conserved serine/threonine phosphatases—and its regulation by specific binding partners, the PPP1-interacting proteins (PIPs).
We combine molecular biology, proteomics, and cell-based approaches to:
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Map and characterise PPP1 interactomes in male reproductive and prostate tissues.
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Identify and validate PPP1/PIP complexes as potential biomarkers and therapeutic targets.
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Develop molecular tools to modulate PPP1/PIP interactions, supporting translational applications in reproductive and cancer biology.
Beyond research, Fardilha’s Lab is a reference in pedagogical innovation, integrating teaching methodologies such as Problem-Based Learning (PBL), Team-Based Learning (TBL), Spaced Learning (SL), and Research-Based Learning. These practices promote a student-centred and research-driven environment, bridging science, education, and clinical application.
With over a decade of scientific contributions, Fardilha’s Laboratory combines basic and translational research with excellence in education, working to advance molecular biomedicine, train the next generation of scientists, and create meaningful impact on health and society.