FARDILHA'S
LAB

We are pleased to share that the project led by Dr. Joana Santiago has been featured by the University of Aveiro. The FERTI$CAN  project aims to develop an innovative molecular-based method to complement conventional diagnostic tools for male infertility. While male factors contribute to around half of all infertility cases, diagnosis remains largely dependent on semen analysis assessing concentration, motility and morphology. In a significant proportion of cases, results fal

We are pleased to share that our latest research, “Proteomic dynamics of bull sperm during post-testicular maturation,” has been published in BMC Genomics by Inês Leites, Patrícia Diniz,  Margarida Fardilha ,  Joana Santiago , Graça Ferreira-Dias, Luís Lopes-da-Costa, and Elisabete Silva. This study provides a comprehensive proteomic characterisation of bovine sperm throughout epididymal transit, revealing dynamic metabolic reprogramming, vesicle-mediated interactions during

Under the framework of the SpermXYSort project, members of Fardilha’s Lab, together with Prof. Bruno Colaço and Cândida Cruz, visited the rabbit breeding facility at Sociedade Agrícola Fonte do Ouro. Our primary objective was to engage with the producer to understand the current challenges in reproduction. Since our project is dedicated to developing a novel sperm sexing method, these on-site insights are critical for tailoring our approach to optimize breeding efficiency whi

We are pleased to share the publication of the article “Screening anticancer peptides performance in organotypic prostate tumor–stroma 3D models” by Bárbara Matos, Maria V. Monteiro, Matilde R. Lagarto, John Howl, Carmen Jerónimo, Vítor M. Gaspar, João F. Mano and Margarida Fardilha, published in the International Journal of Cancer.  This study addresses prostate cancer as a persistent therapeutic challenge and explores the potential of anticancer peptides targeting protein–p

We are pleased to announce the publication of the article “Galectin-3 (Gal-3) Inhibitors as Radiosensitizers for Prostate Cancer” by Renato M. Rodrigues, Bárbara Matos, Vera Miranda-Gonçalves, Carmen Jerónimo and Margarida Fardilha, published in Therapeutics (2026, 3(1), 7).  In this study, we addressed radioresistance as a major therapeutic challenge in prostate cancer by investigating the role of Galectin-3 (Gal-3) and the impact of its pharmacological inhibition using GB11

We are pleased to share that  Joana Santiago , researcher at  Fardilha's Laboratory - Institute of Biomedicine, University of Aveiro , took part in an episode of the “90 Seconds of Science” podcast, where she discussed the FERTI$CAN project and its contribution to improving the diagnosis and prognosis of male infertility. The project focuses on identifying sperm biomarkers to support more accurate and personalised fertility treatments, and is funded by the Portuguese Foundati

We are pleased to share that Professor Margarida Fardilha  and Renato M. Rodrigues  are now members of the new Pedagogical Council , which officially took office on 10 December 2025 . This appointment reflects our continued commitment to advancing high-quality teaching, strengthening pedagogical innovation, and enhancing the academic experience within our institution. We look forward to contributing to a collaborative, student-centred and excellence-driven educational environ

We are thrilled to share our latest contribution to the field of toxicology and environmental health, titled "Hazard identification and characterization of leachable chemicals from plastic products – a new PARC project." As part of the European Partnership for the Assessment of Risks from Chemicals (PARC), this work focuses on a critical challenge of our time: understanding the chemical mixtures leaching from everyday plastic products and their potential impact on human healt

We are proud to share that our systematic review, Exposure to mercury and human reproductive health: A systematic review (Henriques, M.C., Loureiro, S., Fardilha, M., Herdeiro, M.T.; Reproductive Toxicology, 85:93–103), has been cited in a recent report by the Health and Environment Alliance (HEAL). The report warns that chemical pollution is driving a growing men’s health crisis in Europe, with increasing rates of prostate and testicular cancer and male infertility linked to

The University of Aveiro (UA) has recognised the outstanding contributions of Prof. Margarida Fardilha and Catarina Leitão by awarding them for their innovative project “NISA – Level Up to Integrate: Digital Strategies for Academic Success” , as part of the “Incentives for Pedagogical Innovation Projects – More Digital Boost” competition. The project aims to enhance academic success through the development and implementation of digital strategies that support student learning

Our recent paper, “Exploring the feasibility of PP1-docking motif-mimetic cell-penetrating peptides for modulating prostate carcinogenesis” , investigates how PP1-docking motif–mimetic peptides  can be used as a novel strategy to modulate prostate cancer progression . The study bridges molecular mechanisms  and translational therapeutic perspectives , highlighting the potential of targeting PP1-regulatory interactions as an innovative approach in prostate cancer biology. This

Our recent paper, “Mercury exposure and male fertility: Studying the impact of environmental bioaccumulation on semen quality”, explores how environmental mercury exposure may affect male reproductive health. The study examines the biological mechanisms of mercury bioaccumulation and its potential influence on semen parameters, highlighting the broader implications of environmental contaminants on human fertility. This work contributes to the growing body of evidence linking

Join us online on Friday, 24 October (14:30–18:30) for a unique event that brings together educators, students, and researchers to...

We are pleased to announce our latest article: “Endothelial responses to angiogenic modulators highlight metabolic mechanisms underlying...

We are delighted to announce that Anna Kobrock , PhD candidate in Biomedical Sciences at ICBAS – Instituto de Ciências Biomédicas Abel...

As part of her research at iBiMED – Institute of Biomedicine, University of Aveiro , Professor Margarida Fardilha  integrates the...

Prof. Margarida Fardilha, coordinator of the Fardilha's Lab, takes the spotlight in the opening episode of the new season of UA’s...

We are proud to announce the publication of our new study, “Identification of the PP1 interactome in human dental pulp: Insights for...

Prof. Margarida Fardilha , Associate Professor with Habilitation at the Department of Medical Sciences and Coordinator of Fardilha’s...

Fardilha's lab just had published a new systematic review that highlights the effect of nutrition on aging! Congratulations to all the...

A new article is out! Find out more about the most recent work from our group about differentially expressed proteins patterns in the...

We just published a new article to unravel PCa markers in urine. Urine may be a non-invasive sample with prostatic secretions...

The Portuguese Cancer Research Association (ASPIC) highlighted our paper "Photodynamic therapy of prostate cancer using porphyrnic...

We published a new paper ! Find out more about Photodynamic therapy in prostate cancer . Find out more in https://doi.org/10.1016/j.jphot...

Modulation of serine/threonine-protein phosphatase 1 (PP1) complexes: a promising approach in cancer treatment This work rigorously reviewes the potential of modulating PP1 complexes in cancer treatment and highlights the need of the precise identification of PP1 complexes in several cancer models, and the molecular characterization of these complexes both in vitro and in vivo, in order to elucidate their therapeutic potential. Authors also st

We published a new paper ! Find out more about Protein agregation patterns in breast cancer . Open Access: https://www.mdpi.com/2072-6694...

An entitled study “Brain and testis: more alike than previously thought?” published in Open Biology, from The Royal Society suggests that...

We published a new paper today! Find out more about bovine semen sexing and what are the sperm membrane proteomics candidates for...

Congratulations to the most recent PhD from our lab! Juliana Felgueiras has defended her PhD thesis untitled "Unraveling the interactome...

Our new paper on the "Fighting Bisphenol A-Induced Male Infertility: The Power of Antioxidants" is out. Congratulations to all the...

Congratulations to the authors for the new paper, an outcome from the 2MOVEorNOT2MOVE project! Find out more https://doi.org/10.1016/j.fe...

Our new paper on the "New evidences of ubiquitin–proteasome system activity in human sperm" is out. Authors highlighted that the...

Our new paper from the RUNaway project is out! Chronic exercise training attenuates prostate cancer-induced molecular remodelling in the...

And our most recent papers are out! We would like to congratulate all the authors who have been part of to this success by publishing...

Professor Margarida Fardilha presented the Fardilha's lab work and investigation in male infertility and the cell signal pathways in an...

Congratulations to all the authors, in special to authors from our team Juliana Felgueiras, Joana Vieira Silva and Margarida Fardilha!...

We have the pleasure to announce the most recent book Tissue-Specific Cell Signalling edited by Joana Vieira Silva, Maria João Freitas...

Our latest article in Drug Discovery Today "The mammalian two-hybrid system as a powerful tool for high-throughput drug screening" has...

Our most recent published work by Joana Santiago, Joana Vieira Silva and Margarida Fardilha. Find more in: https://www.mdpi.com/1422-0067...

A new paper as been published with the participation of Fardilha's Laboratory. Congratulations to all the authors, specially to Juliana...

The most recent published article from Fardilha's lab. The paper aimed to assess the effect of high intensity, high-volume swimming in...

Fardilha's lab has a new PhD student. Congratulations to Bárbara Matos for the successful FCT application grant this year.

The PhD student from our laboratory, Joana Santiago, participates in the 5th Informative flyer from PO CH (Programa Operacional Capital...

The most recent published article from Fardilha's lab. The article is the first "to associate the mTOR signaling pathway with the age...

Margarida Fardilha has participate in the Europhosphatase: From Molecular Mechanisms to System-wide Responses 2019, a FEBS advanced...

A new paper as been published with the participation of Fardilha's Laboratory. Congratulations to all the authors, specially to Joana...

Today, the paper "Contribution of the unfolded protein response to breast and prostate tissue homeostasis and its significance to cancer...

The most recent published article from Fardilha's lab. Congrats to the authors from our team, Inês Direito and Margarida Fadilha!

Our most recent published work. Congratulations to all the authors, specially to Mónica Ferreira and Margarida Fardilha. Read more:...

Fardilha's lab has 3 new PhD students. Congratulations to Joana Santiago, Daniela Patrício and Tânia Lima for the successful applications.