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Endothelial responses to angiogenic modulators highlight metabolic mechanisms underlying vascular dysfunction in preeclampsia

  • Sep 30, 2025
  • 1 min read

We are pleased to announce our latest article:

“Endothelial responses to angiogenic modulators highlight metabolic mechanisms underlying vascular dysfunction in preeclampsia.”


🔬 In this study, we investigated how an elevated sFlt-1/PlGF ratio – a hallmark of preeclampsia (PE) – impairs endothelial cell metabolism, leading to cytotoxicity, oxidative stress, and mitochondrial dysfunction.


Key findings:


  • In PE patients, circulating sFlt-1 levels correlated with succinate and glycine, unveiling potential metabolic biomarkers.

  • In vitro, increasing sFlt-1/PlGF ratios triggered endothelial damage and oxidative stress-related lipid peroxidation.

  • Endothelial cells exposed to angiogenic imbalance underwent metabolic reprogramming, highlighting mitochondrial adaptations.



💡 These results provide mechanistic insights into how angiogenic imbalance contributes to vascular dysfunction in PE and suggest that metabolic markers such as succinate and glycine may serve as novel tools for risk stratification and disease monitoring.


 
 
 

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