Identification of the PP1 interactome in human dental pulp: Insights for regenerative strategies

We are proud to announce the publication of our new study, “Identification of the PP1 interactome in human dental pulp: Insights for regenerative strategies”, in Cellular Signalling. 

In this work led by Anna Kobrock, Daniela Patrício, Bárbara Matos, Eduardo Zarzuela, Javier Muñoz, John Howl, Pedro S. Gomes and Margarida Fardilha, we investigated the network of protein interactions involving Protein Phosphatase 1 (PP1) in human dental pulp.   We show that all three PP1 isoforms (α, β, γ) are expressed in dental pulp cell lines, and using co-immunoprecipitation coupled with mass spectrometry, we identified 258 putative PP1γ regulatory interactors (RIPPOs). 

Of special interest are proteins such as RRBP1 and THBS1, which may play key roles in odontoblast-like differentiation and mineralization, making them promising targets for strategies aimed at pulp repair and regeneration. 

This is the first comprehensive mapping of the PP1 interactome in dental pulp, laying the groundwork for future work to modulate PP1 activity in therapeutic regenerative endodontics. 

Read more here:

https://www.sciencedirect.com/science/article/pii/S0898656825005479?via%3Dihub