Joana Santiago
About
Joana Santiago holds a bachelor’s degree in Biomedical Sciences in Histocellular Pathology (Higher School of Health Technologies of Lisbon, Portugal) and a master’s degree in Molecular and Cellular Biology (University of Aveiro, Portugal). Her master thesis entitled "Modulation of sperm motility using cell-penetrating peptides" was developed at the Institute of Biomedicine - iBiMED/University of Aveiro (Aveiro, Portugal), under the supervision of Professor Margarida Fardilha and Doctor Joana Vieira Silva.
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Joana had a research fellow position in the project "Protein-protein interactions as drug targets: modulation of Phosphoprotein Phosphatase 1 complexes in male fertility", at Fardilha's Lab, which resulted in 1 published paper and several poster communications. Currently, she is developing her PhD research at the Institute of Biomedicine- iBiMED/University of Aveiro and her project aims to study the transcriptome and proteome of subfertile men in specific conditions, including advanced age and exposure to BPA, to recognize potential biological markers of sperm quality decline and poor fertility, which already resulted in 3 published paper and 1 submitted.
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Her research interests comprise male fertility and reproduction, ageing, biomarkers, sperm biology, RNAs and protein-protein interactions.
Publications
Papers
Santiago, J., Silva, J. V., Santos, M. A. S., and Fardilha, M. (2021). Fighting Bisphenol A Induced Male Infertility: The Power of Antioxidants. Antioxidants, 10(2), 289. https://doi.org/10.3390/antiox10020289
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Silva, J. V., Freitas, M. J., Santiago, J., Jones, S., Guimarães, S., Vijayaraghavan, S., … Fardilha, M. (2021). Disruption of protein phosphatase 1 complexes with the use of bioportides as a novel approach to target sperm motility. Fertility and Sterility, 115(2), 348–362. https://doi.org/10.1016/j.fertnstert.2020.08.013
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Silva, J. V., Santiago, J., Sousa, M., Oliveira, P. F., and Fardilha, M. (2021). New evidences of ubiquitin–proteasome system activity in human sperm. Biochimica et Biophysica Acta - Molecular Cell Research, 1868(3), 16–19. https://doi.org/10.1016/j.bbamcr.2020.118932
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Santiago, J., Santos, M. A. S., Fardilha, M., and Silva, J. V. (2020). Stress response pathways in the male germ cells and gametes. Molecular Human Reproduction, 26(1), 1–13. https://doi.org/10.1093/molehr/gaz063
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Santiago, Silva, Fardilha, Santiago, J., Silva, J. V, and Fardilha, M. (2019). First Insights on the Presence of the Unfolded Protein Response in Human Spermatozoa. International Journal of Molecular Sciences, 20(21), 5518. https://doi.org/10.3390/ijms20215518
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Santiago, J., Silva, J. V, Alves, M. G., Oliveira, P. F., and Fardilha, M. (2018). Testicular Aging: An Overview of Ultrastructural, Cellular, and Molecular Alterations. The Journals of Gerontology: Series A, 00(00), 1–12.
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Book chapter
Santiago, J., Patrício, D., and Silva, J. V. (2020). Testicular Signaling: Team Work in Sperm Production. In Silva J., F. M., and F. M (Eds.), Tissue-Specific Cell Signaling (1st ed., pp. 225–255). Cham: Springer International Publishing. https://doi.org/10.1007/978-3-030-44436-5_8