The mammalian two-hybrid system as a powerful tool for high-throughput drug screening
Our latest article in Drug Discovery Today "The mammalian two-hybrid system as a powerful tool for high-throughput drug screening" has just published.
Congratulations to the authors!
Daniela Patrício & Margarida Fardilha
Authors reviewed the mammalian two-hybrid assay (MTH) and its contribution to protein–protein interaction (PPI) modulation and the search for new potential drugs. In this review, authors described methodologies developed from MTH and the role of these adaptations in PPI discovery. Authors also highlighted the powerful contribution of MTH to the identification of disease-related PPIs and its use in the development of potential new drug screens.
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