Dr. Joana Santiago has been featured by the University of Aveiro.
We are pleased to share that the project led by Dr. Joana Santiago has been featured by the University of Aveiro. The FERTI$CAN project aims to develop an innovative molecular-based method to complement conventional diagnostic tools for male infertility. While male factors contribute to around half of all infertility cases, diagnosis remains largely dependent on semen analysis assessing concentration, motility and morphology. In a significant proportion of cases, results fal
Proteomic dynamics of bull sperm during post-testicular maturation
We are pleased to share that our latest research, “Proteomic dynamics of bull sperm during post-testicular maturation,” has been published in BMC Genomics by Inês Leites, Patrícia Diniz, Margarida Fardilha , Joana Santiago , Graça Ferreira-Dias, Luís Lopes-da-Costa, and Elisabete Silva. This study provides a comprehensive proteomic characterisation of bovine sperm throughout epididymal transit, revealing dynamic metabolic reprogramming, vesicle-mediated interactions during
Fardilha’s Lab visit to Sociedade Agrícola Fonte do Ouro and lunch with Eng. António Feliz under the SpermXYSort project.
Under the framework of the SpermXYSort project, members of Fardilha’s Lab, together with Prof. Bruno Colaço and Cândida Cruz, visited the rabbit breeding facility at Sociedade Agrícola Fonte do Ouro. Our primary objective was to engage with the producer to understand the current challenges in reproduction. Since our project is dedicated to developing a novel sperm sexing method, these on-site insights are critical for tailoring our approach to optimize breeding efficiency whi
Screening anticancer peptides performance in organotypic prostate tumor-stroma 3D models
We are pleased to share the publication of the article “Screening anticancer peptides performance in organotypic prostate tumor–stroma 3D models” by Bárbara Matos, Maria V. Monteiro, Matilde R. Lagarto, John Howl, Carmen Jerónimo, Vítor M. Gaspar, João F. Mano and Margarida Fardilha, published in the International Journal of Cancer. This study addresses prostate cancer as a persistent therapeutic challenge and explores the potential of anticancer peptides targeting protein–p
Galectin-3 (Gal-3) Inhibitors as Radiosensitizers for Prostate Cancer
We are pleased to announce the publication of the article “Galectin-3 (Gal-3) Inhibitors as Radiosensitizers for Prostate Cancer” by Renato M. Rodrigues, Bárbara Matos, Vera Miranda-Gonçalves, Carmen Jerónimo and Margarida Fardilha, published in Therapeutics (2026, 3(1), 7). In this study, we addressed radioresistance as a major therapeutic challenge in prostate cancer by investigating the role of Galectin-3 (Gal-3) and the impact of its pharmacological inhibition using GB11
